Pharmacyclics [NASDAQ:PCYC]: so close and yet so far |
Companies - Biotechnology Companies | |||
Written by Hugh McManus | |||
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Pharmacyclics is an emerging, small molecule pharmaceutical company located in the environs of Silicon Valley in California. The company had been public for almost fifteen years and has enjoyed both good and bad times. It’s currently recovering from a failed attempt to have a potentially potent anti-cancer drug approved by the FDA. Pharmacyclics has been around for many years. It’s had a difficult time with its lead drug, Motexafin gadolinium (MGd) which it tried to get approved by the FDA: no dice. The drug itself has a novel and interesting mode of action against cancer cells—specifically brain cancer. MGd differentially accumulates in the cells and enhances the effects of ionizing radiation on the cells causing apoptosis or cell death. Clinical trial showed an extension of life of many months for patients suffering from this fatal disease. The drug is back in the clinic undergoing two Phase II trials sponsored by the NCI (National Cancer Institute).
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